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Biomaterials 2
Alida Mazzoli

Seat Ingegneria
A.A. 2016/2017
Credits 6
Hours 48
Period II
Language ENG

Prerequisites
Basic acknowledgments regarding classification and properties of biomaterials for the manufacturing of medical devices.

Learning outcomes
KNOWLEDGE AND UNDERSTANDING:
Once acquired the basic acknowledgements regarding the biomaterials and the medical devices, the course is dedicated to the strengthening of the study ability, the development of biocompatible materials and new applications of materials in medicine. During the course are presented the biomedical applications of materials and particular attention is dedicated to the knowledge and understanding of the chemical composition and of the physical-mechanical properties of materials used in medical/surgical field especially for prostheses. Particular attention is given to the characteristics of biocompatibility, inertness and physiological function of the medical device.. The course analyzes in depth contents regarding design, manufacturing technologies and functional evaluation of natural and artificial materials and systems using chemical and physical characterization facilities and modelling tools.
CAPACITY TO APPLY KNOWLEDGE AND UNDERSTANDING:
This free-choice course, allows the acquisition of knowledge regarding the chemical composition and physical-mechanical properties of materials used in the medical/surgical field especially for prostheses. Moreover will be transfered also information regarding regarding design, manufacturing technologies and functional evaluation of natural and artificial materials and systems using chemical and physical characterization facilities and modelling tools.
TRANSVERSAL SKILLS:
The student will acquire skills in terms of course related proficiency and capacity for self-sustained discussion

Program
DEFINITION OF BIOMATERIAL AND HYSTORICAL OUTLINES. BIOCOMPATIBILITY: definitions; interactions biomaterial/human body; sterilization of medical devices and problems connected with the different presented methods; law regulations in terms of biocompatibility of medical devices. CLASSIFICATION OF MEDICAL DEVICES ON THE BASIS OF THE LAW REGULATIONS. CLINICAL APPLICATIONS OF BIOMATERIALS FOR THE MANUFACTURING OF MEDICAL DEVICES. ORTHOPAEDICS: articular prostheses, bone cements, artificial ligaments, bone fractures fixation. ODONTOSTOMATOLOGY: dental implants, materials for endodontics applications, orthodontics devices. CARDIOVASCULAR: cardiac valves, vascular prostheses. MAXILLOFACIAL SURGERY: bone fillers, custom made prostheses. OFTALMOLOGY: contact lens, artificial crystalline lens. VARIOUS APPLICATIONS: drug delivery devices. ADVANCED TECHNOLOGIES APPLIED TO BIOMATERIALS. SURFACE MODIFICATION OF MATERIALS: plasma-spray, sol-gel methods, pulsed laser desposition, biomimetic treatments. BASICS OF TISSUE ENGINEERING. SOLID FREEFORM FABRICATION IN TISSUE ENGINEERING APPLICATIONS. SEMINARS: software for the analysis and treatment of medical images, basics of the design of custom made prostheses using free-form surface modelling and reverse engineering systems.

Development of the examination
LEARNING EVALUATION METHODS
the evaluation method consists in an oral examination. The student will be required to present the main topics regarding the selection of suitable materials for the design and manufacturing of medical devices.

LEARNING EVALUATION CRITERIA
the student should demonstrate the acquisition of skills in terms of course related proficiency and capacity for self-sustained discussion.

LEARNING MEASUREMENT CRITERIA
during the oral examination will be evaluated the capacity of the student for self-sustained discussion relative to the main topics of the course.

FINAL MARK ALLOCATION CRITERIA
the overall evaluation is set from a maximum scale of thirty cum laude to a minimum of eighteen. The maximun will be assigned to a student that demonstrates the complete acquisition of skills in terms of main topics related proficiency and capacity for self-sustained discussion. The minimum will be assigned to a student that demonstrates a passing grade in terms of main topics related proficiency and capacity for self-sustained discussion.

Recommended reading
B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons “Biomaterials - An introduction to materials in medicine“, 2013 ISBN: 978-0-12-374626-9.

Courses

• Biomedical Engineering (Corso di Laurea Magistrale (DM 270/04))